Edward Castillo's Home Page

Edward Castillo, Ph.D.

Research Scientist, Beaumont Health System Research Institute
Adjunct Associate Professor, CAAM Department, Rice University

Peer-Reviewed Publications

  1. Edward Castillo, Yevgeniy Vinogradskiy, and Richard Castillo. Robust HU-Based CT-Ventilation from an Integrated Mass Conservation Formulation. Medical Physics, 46(11): 5036-5046, 2019. (Editor’s Choice Featured Article)
  2. Girish Nair, Edward Castillo, Nicholas Myziuk, Inga Grills, Craig Stevens, and Thomas Guerrero. Differential Ventilation Pattern on Novel Functional Imaging in a Patient with Unilateral Bronchial Obstruction Caused by Adenoid Cystic Carcinoma. American Journal of Respiratory and Critical Care Medicine, In Press, 2019.
  3. Girish Nair and Edward Castillo. Longitudinal Lung Compliance Imaging in Idiopathic Pulmonary Fibrosis. Radiology, 293(2): 272-272, 2019.
  4. Edward Castillo, Richard Castillo, Yevgeniy Vinogradskiy, Michele Dougherty, David Solis, Nicholas Myziuk, Andrew Thompson, Rudy Guerra, Girish Nair, and Thomas Guerrero. Robust CT-Ventilation from the Integral Formulation of the Jacobian. Medical Physics, 45(5): 2115-2125, 2019. (Editor's Choice Featured Article, Issue Cover Article)
  5. Edward Castillo. Quadratic Penalty Method for Intensity-Based Deformable Image Registration and 4DCT Lung Motion Recovery. Medical Physics, 45(5): 2194-2203, 2019.
  6. Yuncheng Zhong, Yevgeniy Vinogradskiy, Liyuan Chen, Nicholas Myziuk, Richard Castillo, Edward Castillo, Thomas Guerrero, and Steve Jiang. Technical Note: Deriving Ventilation Imaging from 4DCT by Deep Convolutional Neural Network. Medical Physics, 45(5): 2323-2329, 2019.
  7. Nicholas Myziuk, Thomas Guerrero, Gukan Sakthivel, David Solis, Girish Nair, Rudy Guerra, and Edward Castillo. Pulmonary Blood Mass Dynamics on 4DCT During Tidal Breathing Physics in Medicine and Biology, 64(4), 2019.
  8. Abolfazl Pinder, Bernard Jones, Richard Castillo, Edward Castillo, Thomas Guerrero, Karyn Goodman, Tracy Schefter, Jennifer Kwak, Moyed Miften, and Yevgeniy Vinogradskiy. Characterizing Spatial Lung Function for Esophageal Cancer Patients Undergoing Radiotherapy. International Journal of Oncology, Biology, Physics, 103(3): 738-746, 2019.
  9. Yevgeniy Vinogradskiy, Chad Rusthoven, Leah Schubert, Bernard Jones, Austin Faught, Richard Castillo, Edward Castillo, Laurie Gaspar, Jennifer Kwak, Timothy Waxweiler, Michele Dougherty, Dexiang Gao, Craig Stevens, Moyed Miften, Briann Kavanagh, Thomas Guerrero, and Inga Grills. Interim Analysis of a Two Institution, Prospective, Clinical Trial of 4DCT-Ventilaiton-Based Functional Avoidance Radiation Therapy. International Journal of Oncology, Biology, Physics, 102(4): 1357-1365, 2018.
  10. Yevgeniy Vinogradskiy, Austin Faught, Richard Castillo, Edward Castillo, Thomas Guerrero, Moyed Miften, and Arthur Liu. Using 4DCT-Ventilation to Characterize Lung Function Changes for Pediatric Patients Getting Thoracic Radiotherapy Journal of Applied Clinical Medical Physics, 19(5): 407-412, 2018.
  11. Austin Faught, Leah Schubert, Lindsey Olsen, Chad Rusthoven, Edward Castillo, Richard Castillo, Jinjing Zhang, Thomasn Guerrero, and Yevgeniy Vinogradskiy. Functional-Guided Radiotherapy Using Knowledge-Based Planning. Radiotherapy and Oncology, 129(3): 494-498, 2018.
  12. Austin Faught, Yuya Miyasaka, Noriyuki Kadoya, Richard Castillo, Edward Castillo, Yevgeniy Vinogradskiy, and Tokihiro Yamamoto. Evaluating the Toxicity Reduction with CT-Ventilation Functional Avoidance Radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 99(2): 325-333, 2017.
  13. Austin Faught, Tokihiro Yamamoto, Richard Castillo, Edward Castillo, Jingjing Zhang, Moyed Miften, and Yevgeniy Vinogradskiy. Evaluating which Dose-Function Metrics are Most Critical for Functional-Guided Radiotherapy with CT Ventilation Imaging. International Journal of Radiation Oncology, Biology, Physics, 99(1): 202-209, 2017.
  14. Timothy Waxweiler, Leah Schubert, Quentin Diot, Austin Faught, Kelly Stuhr, Richard Castillo, Edward Castillo, Thomas Guerrero, Chad Rusthoven, Laurie Gaspar, Brian Kavanagh, Moyed Miften, and Yevgeniy Vinogradskiy. A Complete 4DCT-Ventilation Functional Avoidance Virtual Trial: Developing Strategies for Prospective Clinical Trials. Journal of Applied Clinical Medial Physics, 18(3): 144-152, 2017.
  15. Min Li, Sarah Castillo, Richard Castillo, Edward Castillo, Thomas Guerrero, Liang Xiao, and Xiao-Lin Zheng. Automated Identification and Reduction of Artifacts in Cine Four-Dimensional Computed Tomography (4DCT) Images using Respiratory Motion Model. International Journal of Computer Assisted Radiology and Surgery, 12(9): 1521-1532, 2017.
  16. Edward Castillo, Richard Castillo, Yevgeniy Vinogradskiy, and Thomas Guerrero. The Numerical Stability of Transformation-Based CT Ventilation. International Journal of Computer Assisted Radiology and Surgery, 12(4): 569-580, 2017.
  17. Min Li, Limei Zhang, Zhikang Xiang, Edward Castillo, and Thomas Guerrero. An Improved Fuzzy C-Means Algorithm for Brain MRI Image Segmentation. 2016 IEEE Conference on Progress in Informatics and Computing (PIC), Shanghai: 336-339, 2016.
  18. Yevgeniy Vinogradskiy, Matthew Jackson, Leah Schubert, Bernard Jones, Richard Castillo, Edward Castillo, Thomas Guerrero, John Mitchell, Chad Rusthoven, Moyed Miften, and Brian Kavanagh. Assessing the Use of 4DCT-Ventilation in Pre-operative Surgical Lung Cancer Evaluation. Medical Physics, 44(1): 200-208, 2016.
  19. Yevgeniy Vinogradskiy, Leah Schubert, Quentin Diot, Tim Waxweiller, Phillip Koo, Richard Castillo, Edward Castillo, Thomas Guerrero, Chad Rusthoven, Laurie Gaspar, Brian Kavanagh, and Moyed Miften. Regional Lung Function Profiles of Stage I and III Lung Cancer Patients: An Evaluation for Functional Avoidance Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics, 95(4): 1273-1280, 2016.
  20. Min Li, Zhikang Xiang, Liang Xiao, Edward Castillo, Richard Castillo, and Thomas Guerrero. GPU-accelerated Block Matching Algorithm for Deformable Registration of Lung CT Images. 2015 IEEE Conference on Progress in Informatics and Computing (PIC), Nanjing: 292-295, 2015.
  21. Douglas Brennen, Leah Schubert, Quentin Diot, Richard Castillo, Edward Castillo, Thomas Guerrero, Mary Martel, Derek Linderman, Laurie Gaspar, Moyed Miften, Brian Kavanagh, Yevgeniy Vinogradskiy. Clinical Validation of 4DCT-Ventilation with Pulmonary Function Test Data. International Journal of Radiation Oncology, Biology, Physics, 92(2): 423-429, 2015.
  22. Richard Castillo, Ngoc Pham, Edward Castillo, Samantha Aso-Gonzalez, Sobiya Ansari, Brian Hobbs, Diana Palacio, Heath Skinner, and Thomas Guerrero. Pre–Radiation Therapy Fluorine 18 Fluorodeoxyglucose PET Helps Identify Patients with Esophageal Cancer at High Risk for Radiation Pneumonitis. Radiology, 275(3): 822-831, 2015.
  23. Abdallah Mohamed, Manee-Naad Ruangskul, Musaddiq Awan, Charles Baron, Jayashree Kalpathy-Cramer, Richard Castillo, Edward Castillo, Thomas Guerrero, Esengul Kocak-Uzel, Jinzhong Yang, Laurence Court, Michael Kantor, Brandon Gunn, Rivka Colen, Steven Frank, Adam Garden, David Rosenthal, and Clifton Fuller. Quality Assurance Assessment of Diagnostic and Therapy-Simulation Computed Tomography Image Registration for Head and Neck Radiotherapy: Anatomic Region-of-Interest-Based Comparison of Rigid and Deformable Algorithms. Radiology, 274(3): 752-763, 2015.
  24. Sarah Castillo, Richard Castillo, Edward Castillo, Peter Balter, Tinsu Pan, Geoffrey Ibbott, Brian Hobbs, and Thomas Guerrero. Evaluation of 4D CT Acquisition Methods Designed to Reduce Artifacts. Journal of Applied Clinical Medical Physics, 15(3), 2014.
  25. David Fuentes, Jessika Contreras, Justin Yu, Renjie He, Richard Castillo, Edward Castillo, and Thomas Guerrero. Morphometry Based Measurements of the Structural Response to Whole Brain Radiation. International Journal of Computer Assisted Radiology and Surgery, DOI: 10.1007/s11548-014-1128-3, 2014.
  26. Yevgeniy Vinogradskiy, Phillip J. Koo, Richard Castillo, Edward Castillo, Thomas Guerrero, Laurie Gaspar, Moyed Miften, and Brian Kavanagh. Comparison of 4DCT-Ventilation with Nuclear Medicine Ventilation-Perfusion (VQ) Imaging: A Clinical Validation Study. International Journal of Radiation Oncology, Biology, Physics, 89(1): 199-205, 2014.
  27. Richard Castillo, Ngoc Pham, Sobiya Ansari, Dmitriy Meshkov, Sarah Castillo, Min Li, Adenike Olanrewaju, Brian Hobbs, Edward Castillo, and Thomas Guerrero. Pre-Radiotherapy FDG PET Predicts Radiation Pneumonitis in Lung Cancer. Radiation Oncology, 9(74), 2014.
  28. Edward Castillo, Richard Castillo, David Fuentes, and Thomas Guerrero. Computing Global Minimizers to a Constrained B-spline Image Registration Problem from Optimal $l_{1}$ Perturbations to Block Match Data. Medical Physics, 41(4), 2014.
  29. Min Li, Xiao-Lin Zheng, Hong-Yan Luo, Richard Castillo, Shao-Xiang Zhang, Li-Wen Tan, Edward Castillo, and Thomas Guerrero. Automated Segmentation of Brain Tissue and White Matter in Cryosection Images from the Chinese Visible Human Dataset. Journal of Medical and Biological Engineering, 34(2), 2014.
  30. Min Li, Edward Castillo, Hong-Yan Luo, Xiao-Lin Zheng, Richard Castillo, Dmitriy Meshkov, and Thomas Guerrero. Deformable Image Registration for Temporal Subtraction of Chest Radiographs. International Journal of Computer Assisted Radiology and Surgery, 9(4):513-522, 2014.
  31. Min Li, Edward Castillo, Xiao-Lin Zheng, Hong-Yan Luo, Richard Castillo, Yi Wu, and Thomas Guerrero. Modeling Lung Deformation: A Combined Deformable Image Registration Method with Spatially Varying Young’s Modulus Estimates. Medical Physics, 40(8), 2013.
  32. Richard Castillo, Edward Castillo, Michelle Ludwig, David Fuentes, Moiz Ahmad, Abbie Wood, and Thomas Guerrero. A Reference Dataset for Deformable Image Registration Spatial Accuracy Evaluation using the COPDgene Study Archive. Physics in Medicine and Biology, 58: 2861-2877, 2013.
  33. Yevgeniy Vinogradskiy, Richard Castillo, Edward Castillo, Susan Tucker, Zhongxing Liao, Thomas Guerrero, and Mary Martel. Use of 4-Dimensional Computed Tomography-Based Ventilation Imaging to Correlate Lung Dose and Function With Clinical Outcomes. International Journal of Radiation Oncology, Biology, Physics, 86: 366-371, 2013.
  34. Alfredo Echeverria, Matthew McCurdy, Richard Castillo, Vincent Bernard, Natalia Ramos, William Buckley, Edward Castillo, Ping Liu, Josue Martinez, and Thomas Guerrero. Proton Therapy Radiation Pneumonitis Local Dose-Response in Esophagus Cancer Patients. Radiotherapy and Oncology, 106: 124-129, 2013.
  35. Matthew McCurdy, Derek Bergsma, Eric Hyun, Thomas Kim, Enid Choi, Richard Castillo, Edward Castillo, and Thomas Guerrero. The Role of Lung Lobes in Radiation Pneumonitis and Radiation-Induced Inflammation in the Lung: A Retrospective Study. Journal of Radiation Oncology, 2: 203-208, 2013.
  36. Lindsay Mathew, Andrew Wheatly, Richard Castillo, Edward Castillo, George Rodrigues, Thomas Guerrero, and Grace Parraga. Hyperpolarized 3He Magnetic Resonance Imaging: Comparison with Four-dimensional x-ray Computed Tomography Imaging in Lung Cancer. Academic Radiology, 19: 1546-1553, 2012.
  37. Edward Castillo, Richard Castillo, Benjamin White, Javier Rojo, and Thomas Guerrero. Least Median of Squares Filtering of Locally Optimal Point Matches for Compressible Flow Image Registration. Physics in Medicine and Biology, 57: 4827-4833, 2012.
  38. Edward Castillo, Jian Liang, and Hongkai Zhao. Point Cloud Segmentation and Denoising via Constrained Nonlinear Least Squares Normal Estimates. Book Chapter on: Innovations for Shape Analysis: Models and Algorithms, Springer, 2012.
  39. Richard Castillo, Edward Castillo, Mathew McCurdy, Daniel R. Gomez, Alec M. Block, Derek Bergsma, Sarah Joy, and Thomas Guerrero. Spatial Correspondence of 4D CT Ventilation and SPECT Pulmonary Perfusion Defects in Patients with Malignant Airway Stenosis. Physics in Medicine and Biology, 57: 1855-1871, 2012.
  40. Yevgeniy Y. Vinogradskiy, Richard Castillo, Edward Castillo, Adam Chandler, Mary K. Martel, and Thomas Guerrero. Use of Weekly 4DCT-based Ventilation Maps to Quantify Changes in Lung Function for Patients Undergoing Radiation Therapy. Medical Physics, 39: 289-298, 2012.
  41. Richard Castillo, Edward Castillo, Josue Martinez, and Thomas Guerrero. Ventilation from Four Dimensional Computed Tomography: Density Versus Jacobian Methods . Physics in Medicine and Biology, 55: 4661-4685, 2010.
  42. Edward Castillo, Richard Castillo, Josue Martinez, Maithili Shenoy, and Thomas Guerrero. Four Dimensional Deformable Image Registration Using Trajectory Modeling. Physics in Medicine and Biology, 55: 305-327, 2010.
  43. Xuejun Gu, Hubert Pan, Yun Liang, Richard Castillo, Deshan Yang, Dongju Choi, Edward Castillo, Amitava Majumdar, Thomas Guerrero, and Steve Jiang. Implementation and Evaluation of Various Demons Deformable Image Registration Algorithms on GPU. Physics in Medicine and Biology, 55: 207-219, 2010.
  44. Edward Castillo, Richard Castillo, Yin Zhang, and Thomas Guerrero. Compressible Image Registration for Thoracic Computed Tomography Images. Journal of Medical and Biological Engineering, 29: 222-233, 2009. (JMBE Highlights of 2009 Article)
  45. Richard Castillo, Edward Castillo, Rudy Guerra, Valen Johnson, Travis McPhail, Amit Garg, and Thomas Guerrero. A Framework for Evaluation of Deformable Image Registration Spatial Accuracy Using Large Landmark Point Sets. Physics in Medicine and Biology, 54: 1849-1870, 2009. (PMB Featured Article 2009)
  46. Thomas Guerrero, Kevin Sanders, Edward Castillo, Yin Zhang, Luc Bidaut, Tinsu Pan, and Ritsuko Komaki. Dynamic Ventilation Imaging from Four-Dimensional Computed Tomography. Physics in Medicine and Biology, Vol. 51: 1-15, 2006.
  47. Thomas Guerrero, Kevin Sanders, Josue Noyola-Martinez, Edward Castillo, Yin Zhang, Richard Tapia, Rudy Guerra, Yerko Borghero, and Ritsuko Komaki. Quantification of Regional Ventilation from Treatment Planning CT. International Journal of Radiation Oncology, Biology, Physics, 62: 630-634, 2005.


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